The crusaders' conquest of 1099 brought fundamental change to Jerusalem which became a Christian city. The number of Latin pilgrims and poor increased, the Holy Sepulchre was occupied by Latin canons and the Greek Patriarch was replaced by a Latin one. The Benedictines of Sancta Maria Latina lost their predominance in Jerusalem. The Latin hospice survived under its competent leader Girardus; it was detached from Sancta Maria Latina and was somehow associated with the Holy Sepulchre nearby. It expanded greatly and reincorporated the female.

Bolla di Pasquale II "Pie postulatio".